MO917INFLAMMATORY PARAMETERS IMPROVEMENT WITH CITRATE COMPARED TO ACETATE DIALYSATE

Abstract Background and Aims The relation between inflammation cardiovascular disease is well established. Dialysis patients are at a higher risk of death, mostly attributed to disease. This study evaluated the potential benefits citrate (CD) vs. acetate dialysate (AD) regarding patients’ inflammatory status. Method Single-center, cross-over, prospective study, with follow-up total 24 dialysis sessions, 12 each dialysate. Blood samples were taken on twelfth session type Every patient acted as its own control. pre-dialysis parameters analyzed procalcitonin (PCT), high-sensitivity C-reactive protein (hsCRP) interleukin-6 (IL-6). Results Pre-dialysis hsRCP [AD: 4,32 (1,27 – 12,16) CD: 4,08 (0,98 8,65) mg/L, p = 0,031], PCT 0,44 (0,28 0,74) 0,38 (0,29 0,44) ng/mL, 0,037], IL-6 13,7 (7,85 29,03) 11,8 (5 27,13) pg/mL, 0,029] significativly after twelve sessions AD CD. Conclusion Even in medium term, use instead acidifier, reduces measured could therefore be considered more biocompatible option.